摘要
乙型肝炎病毒(HBV)感染是一个影响全球的健康问题。HBV有8种基因型,呈地域性分布。研究表明HBV基因型对慢性HBV感染的自然病程、临床结局、抗病毒治疗等具有影响。A基因型与C基因型与严重的肝损害相关;A基因型与B基因型对干扰素的应答率分别较D基因型与C基因型均更高;有研究发现HBV的基因型可能影响HBV的传播途径。然而,目前大多数临床资料来自亚洲及对B、C基因型的相关研究,基于基因型的地域性分布,对HBV基因型的全面认识,还有待进一步的国际化合作。
Hepatitis B virus （HBV） infection is a global health problem. Eight genotypes of HBV are identified and most have specific geographic distribution. The impact of HBV genotypes on the natural course, clinical outcome, antiviral therapy of chronic HBV infection has been studied. Genotype A and C are associated with more severe liver injury compared with genotype B and D. HBV genotype A and B have better response to interferon （IFN） treatment compared with genotype D and C. Some studies demonstrated that HBV genotype may influence transmission ways of HBV. However, most clinical data came from Asia and provided findings in patients infected with genotypes B and C. Because of geographic distribution of HBV genotype, more international cooperative studies to further clarify HBV genotype should be performed.
出处
《国际内科学杂志》
CAS
2007年第3期180-183,126,共5页
International Journal of Internal Medicine
