摘要
目的研究黄蜀葵总黄酮(TFA)抗脑卒中后抑郁(PSD)的作用。方法采用线栓法制备局灶性脑缺血大鼠模型,在此基础上综合孤养、应激处理复制PSD大鼠模型。观察TFA对PSD大鼠开野行为、血液流变学以及脑组织脂质过氧化的影响。结果TFA可增加PSD大鼠的水平与垂直运动得分;抑制PSD大鼠各切变率下全血黏度、血浆黏度的升高,提高红细胞的变形性;提高脑组织中超氧化物岐化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性,降低丙二醛(MDA)含量。结论TFA具有抗PSD作用,其机制可能与改善血液流变学、抗脂质过氧化作用有关。
OBJECTIVE： To study the antidepressant effects of total flavone of A（TFA） on post stroke depression （PSD） in rats. METHODS： Middle cerebral artery occlusion （MCAO） followed by isolation feed and irritable stimuli was used to induce PSD. Behaviours of rats were detected by open - field test .The effects of TFA on the indexes of hemorheology and brain homogenate lipid peroxidation were also tested. RESULTS： TFA could increase the crossing and rearing scores in open-field test, inhibit the elevation of whole blood viscosity as well as plasma viscosity at high- middle- low shear rates, increase the erythrocyte deformation, enhance the activities of Superoxide Dismutase （SOD） and Glutathione Peroxidase （GSH-Px）, and reduce Malondialdehyde （MDA） content in brain homogenate in PSD in rats. CONCLUSIONS： TFA produces an antidepres- sant- like effect in PSD rats. This mechanism may be in association with attenuating hemorheological parameters and decreasing lipid peroxidative damage.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第12期885-887,共3页
China Pharmacy
基金
安徽省科技厅年度重点项目(05021005)
关键词
黄蜀葵总黄酮
卒中后抑郁
开野试验
血液流变学
脂质过氧化
Total flavone of A
Post - stroke depression
Open - field test
Hemorheology
Lipid peroxidation
