摘要
目的研究黄蜀葵总黄酮(TFA)抗脑卒中后抑郁(PSD)的作用。方法采用线栓法制备局灶性脑缺血大鼠模型,在此基础上综合孤养、应激处理复制PSD大鼠模型。观察TFA对PSD大鼠开野行为、血液流变学以及脑组织脂质过氧化的影响。结果TFA可增加PSD大鼠的水平与垂直运动得分;抑制PSD大鼠各切变率下全血黏度、血浆黏度的升高,提高红细胞的变形性;提高脑组织中超氧化物岐化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性,降低丙二醛(MDA)含量。结论TFA具有抗PSD作用,其机制可能与改善血液流变学、抗脂质过氧化作用有关。
OBJECTIVE: To study the antidepressant effects of total flavone of A(TFA) on post stroke depression (PSD) in rats. METHODS: Middle cerebral artery occlusion (MCAO) followed by isolation feed and irritable stimuli was used to induce PSD. Behaviours of rats were detected by open - field test .The effects of TFA on the indexes of hemorheology and brain homogenate lipid peroxidation were also tested. RESULTS: TFA could increase the crossing and rearing scores in open-field test, inhibit the elevation of whole blood viscosity as well as plasma viscosity at high- middle- low shear rates, increase the erythrocyte deformation, enhance the activities of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GSH-Px), and reduce Malondialdehyde (MDA) content in brain homogenate in PSD in rats. CONCLUSIONS: TFA produces an antidepres- sant- like effect in PSD rats. This mechanism may be in association with attenuating hemorheological parameters and decreasing lipid peroxidative damage.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第12期885-887,共3页
China Pharmacy
基金
安徽省科技厅年度重点项目(05021005)
关键词
黄蜀葵总黄酮
卒中后抑郁
开野试验
血液流变学
脂质过氧化
Total flavone of A
Post - stroke depression
Open - field test
Hemorheology
Lipid peroxidation