3-氯-1,1-环丁烷二羧酸根·二氨合铂(Ⅱ)的合成及抗肿瘤活性研究

Synthesis and Anticancer Activity of 3-chloro-1,1-dicarboxycyclobutane Diammine Platinum(II)

根据目前临床使用的铂类抗癌药物的缺点和不足,作者报道了一种结构新颖的铂类配合物的合成方法,通过元素分析、质谱、红外和核磁共振氢谱等对合成物进行了结构表征,确认合成物为目标化合物。采用SRB比色法,测定该化合物对A549细胞及KB细胞的半数抑制浓度(IC50)分别为4.8mg/L和18.0mg/L。

Platinum-based drugs are one of the most important anticancer drugs in clinical use. In this paper, a new platinum-based complex, 3-chloro-1,1-dicarboxycyclobutane diammine platinum（Ⅱ） was synthesized and its structures was characterized by element analysis, MS, IR, and IH-NMR. The synthesized complex is confirmed to be the target compound, The IC50 of the compound is 4.8mg/L for A549 cell and 18.0 mg/L for KB cell respectively.