生肌散质控方法的研究

Study on Quality Control of Shengji San

目的 建立生肌散的质量标准。方法 采用TLC法对处方中血竭、冰片进行鉴别，用HPLC法测定方中君药儿茶中儿茶素的含量。结果 在TLC色谱中，能检出血竭、冰片。儿茶素在0．1762～3．524μg范围内，浓度与峰面积线性关系良好（r=0．9994），样品的平均加样回收率为103．06％，RSD为0．39％（n=6）。结论 本文建立的方法对方中3味药材能准确、快速地进行定性、定量检测，可用于生肌散的质量控制。

Aim To develop methods quality control of Shenji san. Methods TLC was applied to sanguis draxonis, borneolum syntheticum to determine the content of catechin of catechu using HPLC. Results Sanguis draxonis, borneolum syntheticum could be indentified by TLC. Catechin showed a good linear relationship within the range of 0. 176 2 - 3. 524μ g, r = 0. 999 4. The average recovery was 103.06%, and RSD was 0.39%. Conclusion The method is accurate, quick and can be used for quality control of Shenji san.