PTEN及p27^Kip1在子宫内膜癌中的研究进展

Advance in PTEN Gene and p27^Kip1 gene in Endometrial Carcinoma

肿瘤抑制基因PTEN被称为子宫内膜的看家基因，许多学者提出PTEN基因在子宫内膜癌发生发展中起重要作用。另一个肿瘤抑制基因p27在子宫内膜癌的预后中具有重要的作用。现就PTEN、p27基因在子宫内膜癌中的表达及其与子宫内膜癌发生、发展的关系以及在治疗和预后方面的研究进展进行综述。

PTEN ,a novel tumor suppressor gene identified recently, is called the house-keeping gene of endometrium. Many researchers indicate that PTEN play important roles in genesis and development of endometrial carcinoma. An other novel tumor suppressor gene, p27, plays a key role in prognosis of endometrial carcinoma. This article dicusses the expression of PTEN gene and p27 gene in endometrial carcinoma, and the relation with development, therapeutic effect and prognosis of the disease.