摘要
目的:探讨桂皮醛解热作用及其作用机制。方法:采用酵母诱致大鼠发热模型和白细胞介素-1β(IL-1β)刺激小鼠脑微血管内皮细胞(bEnd.3)作为实验体系,采用酶联免疫法(ELISA)测定致热大鼠下丘脑组织及bEnd.3细胞上清液中前列腺素E2(PGE2)含量。结果:桂皮醛能有效抑制酵母所致大鼠发热反应,显著降低发热大鼠下丘脑PGE2含量,亦能明显抑制IL-1β刺激bEnd.3细胞PGE2的释放。结论:桂皮醛具有明显的解热作用,其解热机制可能与影响PGE2含量有关。
Objective：To investigate the antipyretic effect and its mechanism of cinnamaldehyde. Methods：The rat febrile models induced by injecting fresh yeast subcutaneously and the mouse cerebral microvascular endothelial cells （bEnd. 3 ） stimulated by IL-1β were adopted in the experiment. The contents of PGE2 in the hypothalamus and in conditioned media of bEnd. 3 stimulated by IL-1β were measured by ELISA, respectively. Results： Cinnamaldehvde showed marked antipyretic effect on the yeast-induced fever, and remarkable decreased the contents of PGE2 in the hypothalamus of febrile rats and in the conditioned media of bEnd. 3 induced by IL-1β. Conclusions： Cinnamaldehyde has obvious antipyretic effect, which might be related with the interferencing the content of PGE2.
出处
《中国实验方剂学杂志》
CAS
2007年第4期22-25,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金资助课题(30572358)
关键词
桂皮醛
解热
前列腺素E2
下丘脑
脑微血管内皮细胞
Cinnamaldehyde
pyretolysis
prostaglandin E2
hypothala-mus
cerebral microvascular endothelial cell
