新伯氏液基薄层细胞学筛查宫颈病变的研究

ThinPrep Liquid-based Cytology Test for Cervical Lesion Screening in Guangdong Province

目的新伯氏液基薄层细胞学在筛查宫颈癌及癌前病变中的临床应用。方法24786名妇女进行了液基薄层细胞学检查，细胞学评价方法采用TBS（the Bethesdas ystem）分级系统（2001年修订）。结果24786名受检妇女中，不典型鳞状细胞（ASC）和不典型腺细胞（AGC）的阳性率为6．17％，鳞状上皮内低度病变（LSIL）的阳性率为1．70％，鳞状上皮内高度病变（HSIL）的阳性率为0．61％，宫颈癌的发病率为0．11％。41-50岁年龄组的宫颈癌检出率为0．16％，21-30岁年龄组的宫颈癌检出率为0．07％。41-50岁年龄组的SIL检出率为2．77％。41-50岁年龄组与51。印岁年龄组LSIL以上病变的阳性率差异有统计学意义（P〈0．01）。广州、东莞、深圳宫颈癌的检出率分别为0．14％、0．12％、0．06％，LSIL以上病变的阳性率分别为2．70％，1．98％，1．93％。结论新伯氏液基薄层细胞学是筛查宫颈癌及癌前病变的一种有效方法，30岁以上妇女要定期进行妇科检查。

Objective To assess the utility of ThinPerp liquid - based cytology test for cervical lesion screening in clinical practice in Guangdong province. Methods 24 786 cervical specimens were processed with the ThinPrep liquid- based cytology test and evaluated according to the 2001 Bethesdasystem. Results A total of 24 786 cases was diagnosed by cytology test , amongwhich 6.17% with atypical squamous cells （ASC） and atypical glandular cells （AGC）, 1.70% with low- grade squamous intraepithelial lesion （LSIL）, 0.61% with high- grade squamous intraepithelial lesion （HSIL）, 0.10% with squamous cell carcinoma and 0.01% with adenocarcinoma.The incidence of cervical carcinoma was 0.16% among age 41 - 50, 0.07% among age 21 - 30.Age 41 -50 has high rate （2.77%） of SIL.Significant differences in squamous intraepithelial lesion appear between age 41 - 50 and 51 - 60 （P 〈 0.01）. The corresponding incidences of cervical carcinoma in Guangzhou, Dongguan, Shenzhen, were 0.14%, 0.12%, 0.06%, respectively. Conclusion ThinPrep liquid - based cytology test is an effective method for cervical lesion screening. Women older than 30 age should attend a routine cervical cancer screening.