针刺“内听宫”穴拮抗庆大霉素耳毒性作用的观察

Observation on acupuncture at “Neitinggong” for antagonisting ototoxicity caused by gentamicin

目的:探讨针刺“内听宫”穴治疗药物性耳聋的作用。方法:豚鼠用庆大霉素注射,使之成为药物性耳聋动物模型。分别针刺不同组实验动物的“内听宫”、“听宫”、耳郭缘非穴位区,观察针刺不同穴位对听性脑干反应和耳蜗毛细胞的影响。结果:庆大霉素组的听性脑干反应阈分别与“内听宫”和“听宫”组有统计学差别,与耳郭缘组无统计学差别;“内听宫”组和“听宫”组反应阈之间无统计学差别。耳蜗毛细胞的变化和反应阈的变化相一致。结论:针刺“内听宫”穴能增强内耳的功能,减轻庆大霉素对耳蜗毛细胞的损害作用,是治疗药物性耳聋的有效穴位。

Objective To explore the effect of acupuncture at ＂Neitinggong＂ drug-induced deafness. Methods Guinea pig deafness model was prepared by injection of gentamicin （GM）. Acupuncture was respectively given at the points ＂Neitinggong＂ ＂Tinggong＂ （SI 19） and non-acupoints on the auricle in the experimental animals in different groups and the effects of different points on the auditory brainstem response and cochlear hair cells were observed. Results There was a significant difference between GM group and Neitinggong group, and between GM group and Tinggong group. There was no significant difference between GM group and the auricle group, and between Neitinggong group and Tinggong group. Conclusion Acupuncture at ＂Neitinggong＂ can strength the function of the in- ternal ear, and relieve the injury of cochlear hair cells caused by gentamicin, which is an effective acupoint for treatment of drug-induced deafness.