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系列特异性嵌合体检测在异基因造血干细胞移植中的应用 被引量：2

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摘要 异基因造血干细胞移植（allo—SCT）后动态监测供受者嵌合状态，因其在判断allo—SCT后转归，提高移植成功率等方面的重要意义，现已成为allo—SCT后患者的常规检测项目。采用STR—PCR方法从分子遗传学上检测嵌合状态已在国内外广泛开展。而近年来开展的系列特异性嵌合体的检测，其敏感性和特异性较混合细胞检测为高，临床指导作用更强。本文就系列特异性嵌合体的检测及临床意义作一综述。
作者 张秋蓉（综述） 唐晓文（审校） 吴德沛（审校）
机构地区 苏州大学附属第一医院血液内科江苏省血液病研究所
出处 《国际输血及血液学杂志》 CAS 2007年第2期133-136,共4页 International Journal of Blood Transfusion and Hematology
关键词 嵌合体 干细胞移植 短串联重复序列
分类号 R457.7 [医药卫生—治疗学]
  • 相关文献

参考文献18

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二级参考文献2

共引文献14

同被引文献26

  • 1Michallet AS,Fürst S,Ie QH,et al.Impact of chimaerism analysis and kinetics on allogeneic haematopoietic stem cell transpl antation outcome after conventional and reduced-intensity conditioning regimens.Br J Haematol,2005,128(5):676-689.
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  • 3Jaksch M,Uzunel M,Remberger M,et al.Molecular monitoring ofT-cell chiimerism early after allogeneic stem cell transplantation may predict the occurrence of acute GVHD grades Ⅱ -Ⅳ.Clin Transplant,2005,19(3):346-349.
  • 4Miura Y,Tanaka J,Toubai T,et al.Analysis of donor-type chimerism in lineage-specific cell populations after allogeneic myeloablative and non-myeloablative stem cell transplantation.Bone Marrow Transplant,2006,37(9):837-843.
  • 5Liesveld JL,Rothberg PG.Mixed chimerism in SCT:conflict or peaceful coexistence? Bone Marrow Transplant,2008,42(5):297-310.
  • 6Bader P,Niethammer D,Willasch A,et al.How and when should we monitor chimerism after allogeneic stem cell transplntation? Bone Marrow Transplant,2005,35(2):107-119.
  • 7Beck O,Seidi C,Lehmbecher T,et al.Quantification of chimerism within peripheral blood,bone marrow and purified leukocyte subsets:comparison of singleplex and multiplex PCR amplification of short tandem repeat(STR)loci.Eur J Haematol,2006,76(3):237-244.
  • 8Koldehoff M,Steckel NK,Hinka M,et al.Quantitative analysis of chimerism after allogeneic stem cell transplantation by real-time polymerase chain reaction with single nucleotide polymorphisms,standard tandem repeats,and Y-chromosome-specific sequences.Am J Hematol,2006,81 (10):735-746.
  • 9Eshel R,Vainas O,Shpringer M,et al.Highly sensitive patientspecific real-time PCR SNP assay for chimerism monitoring after allogeneic stem cell transplantation.Lab Hematol,2006,12(1):39-46.
  • 10Willasch A,Schneider G,Reincke BS,et al.Sequence polymorphism systems for quantitative real-time polymerase chain reaction to characterize hematopoietic chimerism-high informativity and sensitivity as well as excellent reproducibility and precision of mesurement.Lab Hematol,2007,13(3):73-84.

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国际输血及血液学杂志
2007年 第2期

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