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NK细胞KIR基因表达调控机制研究进展 被引量:4

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摘要 杀伤细胞免疫球蛋白样受体(KIR)是在自然杀伤NK细胞表面呈克巨性分布,能够识别靶细胞上相应HLAI类分子表位、调节NK细胞活性的一类具有抑制和激活功能的重要受体。KIR基因家族呈随机性、多样性和单一等位基因表达模式。KIR的基因型决定其表达谱,并对KIR的表达频率具有微调作用。转录因子参与调节KIR表达。KIR基因的克隆性表达主要受表观遗传调控,通过DNA甲基化作用维持。对NK细胞KIR表达机制的深入研究有助于在感染性疾病、妊娠、自身免疫性疾病及造血干细胞移植中控制KIR表达。
出处 《国际输血及血液学杂志》 CAS 2007年第2期157-159,共3页 International Journal of Blood Transfusion and Hematology
基金 国家自然科学基金面上项目(30670898).
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同被引文献46

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