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甾醇生物合成中的关键酶—环氧角鲨烯环化酶的分子生物学研究 被引量：14

Development on the Molecular Biology of Oxidosqualene Cyclase-the Key Enzyme in Sterols Biosynthesis
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摘要 植物体中环氧角鲨烯环化酶催化2,3-环氧角鲨烯形成一系列三萜烯,为甾醇和三萜化合物的生物合成提供前体,这一催化反应被认为是甾醇和三萜化合物生物合成分支形成的关键位点.综述了甾醇和三萜化合物生物合成中的关键酶——环氧角鲨烯环化酶(OSCs)家族的生物学功能,基因克隆与属性,酶的细胞定位与酶活的表达调控等分子生物学研究进展. Oxidosqualene cyclases （OSCs） catalyze the cyclization of 2, 3-oxidosqualene, a common biosynthetic intermediate of both triterpenoids and sterols. The critical branching poit for sterol and triterpenoids biosyntheses. The molecular biologyic developments, with particular emphasis on the enzyme function, the gene property and molecular cloning, the protein regulation and cellular localization of the Oxidosqualene cyclases （OSCs） are reviewed.
作者 秦玉芝 赵小英 邓克勤 李旭 刘选明
机构地区 湖南大学生命科学与技术学院
出处 《生命科学研究》 CAS CSCD 2007年第1期10-15,共6页 Life Science Research
基金 湖南省自然科学基金资助项目(99JJY20024)
关键词 环氧角鲨烯环化酶(OSCs) 甾醇 三萜化合物 oxidosqualene cyclases （ OSCs） triterpenoids sterols
分类号 Q946.5 [生物学—植物学]
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参考文献24

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二级参考文献112

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生命科学研究
2007年 第1期

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