摘要
本实验测定了星形聚环氧乙烷聚乳酸嵌段共聚物(S(P)-PEO-PLA)在溶液中核磁驰豫与温度、浓度、溶剂及聚合物组成比的关系,测定了线形嵌段共聚物(L-PEO-PLA)核磁驰豫与温度、聚合物组成比的关系。实验测定了两个驰预参数T_1和η_c。采用Cole-Cole相关时间分布,log-x^2分布及Diamord Lattice模型对测定结果进行了定量解析。本文研究结果为假设的“似细胞超微^+”结构形态的存在性提供了理论依据,表明S(P)-PEO-PLA作为药物载体很有希望。
It is the spin-lattice relaxation time (T_1) and nuclear overhauser enhancement fators (η_c)of the PEO-PLA star-block copolymer(S(p)-PEO-PLA) in solution that are changing withsolvent, concentration, temperature, and Polymer composition. and so do the T_1 and η_c of PEO-PLA line-block copolymer that change along with temperature and Polymer composition. Thesechanges have been determined by the authors. The data thus obtained were quantitatively analy-sed by Cole-Cole correlation time distridution, log-X^2 distridution and diamond model. All theresults supported the 'macrocapsule'scructure which was proposed by this experiment. It wasconcluded that S(p)-PEO-PLA may be a promissing carriere for pharmaceuticals.
关键词
星形聚合物
药物载体
碳13
NMR
Drug carrier
NMR
nuclear magnetic relaxation
molecular motion
star polymer
