部分门静脉动脉化对大鼠肝脏血管铸型变化的影响

The effect of partial portal vein arterialization on changes of hepatic vascular framework in rats

目的探讨用部分门静脉动脉化重建肝血流后对肝脏微血管和组织学的影响。方法建立大鼠部分门静脉动脉化重建肝脏血流的实验模型,观察该模型大鼠肝脏微血管和组织学的变化。结果行门静脉动脉化手术后1个月动物肝脏组织未见明显异常。血管铸型标本显示肝窦略变粗,较正常充盈,肝窦无明显变形,仍呈放射状分布于中央静脉的周围。墨汁灌注标本显示肝窦内墨汁灌注规整,略显增宽,颜色均匀并加深。结论部分门静脉动脉化后在近期内不影响肝脏的微血管及组织学结构。

Objective To study the effect of reconstructed hepatic blood flow after partial portal vein arterialization on hepatic microvasculature and histology. Methods Experimental model of partial portal vein arterialization was established in rats. The changes of hepatic microvasculature and histology in the rat model were observed. Results One month after arterio-portal shunt, the hepatic tissues showed no significant abnormality. However, corrosive cast samples showed that hepatic sinusoids were slightly thicker and their filling was more obvious than normal, but were not obviously deformed, and were distributed around the central vein in a radial form. Ink peffusion samples showed that hepatic sinusoids were regular and slightly wider. Their colour was homogeneous and slightly deeper. Conclusions Partial portal vein arterialization has no early effect on hepatic microvasculature and histologic structure.