成骨生长肽对种植术后放疗骨密度的影响

Effects of osteogenic growth peptide on bone density adjacent to implant in irradiated tibia of the rabbits

目的:探讨种植术后放疗骨密度的变化及使用成骨生长肽对骨密度的影响。方法:在24只兔的胫骨内植入钛种植体48颗,随机分为3组。I组空白对照,II组单纯放疗,III组放疗前每天注入0.5μg/kg成骨生长肽。术后第4周、16周时各处死每组动物4只,通过大体观察、X线检查、双能X线、组织形态学及骨计量学分析骨密度的变化。采用SPSS13.0统计学软件进行组间方差分析。结果:4周时,单纯放疗组种植体周骨密度比空白对照组显著降低(P<0.05),放疗+成骨生长肽组种植体周骨密度与空白对照组差异无显著性;16周时,3组的种植体周围骨密度差异无显著性(P>0.05)。结论:放疗延缓种植体周骨的生长,而全身应用成骨生长肽可以促进骨生长,减轻钛种植术后放疗的骨损伤。

PURPOSE： To evaluate the effect of radiation and osteogenic growth peptide （OGP） on the bone density adjacent to the implants. METHODS： 24 rabbits underwent 48 implants placed in the tibia, then the rabbits were divided into one control group and two experimental groups randomly. Rabbits in one of the experimental groups were injected with OGP Sol, rabbits in the other groups were injected with normal saline;Then rabbits in the two experimental groups received radiation after the implant wound healed. 12 rabbits were sacrificed at 4 weeks and 16 weeks respectively. The samples were observed with gross, X-ray, histological examination. The data was analysed for Dunnett t test using SPSS13.0 software package. RESULTS： At 4 weeks ,the bone density adjacent to the implant of the simple irradiation group was significantly less than that of the control group （P〈0.05）, while the difference was not significant between the irradiation and OGP group and the control group. At 16 weeks, the difference among the three groups wasn＇t significant. CONCLUSIONS： Radiation has considerable adverse effect on osteogenesis adjacent to the implants, while systemically administering OGP plays significant roles in the osteogensis of the irradiated rabbit tibia. Supported by Research Fund of Science and Technology Committee of Xiamen Municipality （Grant No.3502Z20044017）.