IgE介导的小鼠皮肤三相过敏反应模型的研究进展

Progress in the model of IgE-dependent triphasic cutaneous reaction in mice

由anti-DNP IgE单克隆抗体致敏、DNFB激发而形成的IgE介导的小鼠皮肤过敏反应模型于1983年首次被发现,历经了2相(速发相、迟发相)到3相(速发相、迟发相、超迟发相)过敏反应模型的建立、应用,以及造模方法的优化过程,使3相皮肤过敏反应模型逐步健全。3相过敏反应的免疫机制各有不同,本文将对此模型应用及过敏反应免疫机制的研究、抗过敏药物的药效学等进行综述。

The model of IgE -dependent cutaneous reaction in mice was found in 1983 ,which sensitized with anti -DNP IgE mAb and challenged with DNFB. This model turned into triphasic reaction （IPR, LPR and vLPR） from biphasic reaction （ IPR, LPR） . The immunologic mechanism of the triphasic cutaneous reaction was different respectively, which was described in this article. This model had been applicated in some investigations, such as the immunological mechanism of hypersensitive response, pharmacodynamics in antiallergic drugs and the therapy in anaphylactic disease and so on.