帕罗西汀联合普萘洛尔治疗广泛性焦虑症的临床疗效观察

Clinical Effect of Paroxetine and Propranolol in the Treatment of Generalized Anxiety

目的观察帕罗西汀联合普萘洛尔治疗焦虑症的临床疗效和不良反应。方法将205例广泛性焦虑患者随机分为两组,研究组(帕罗西汀联合普萘洛尔)105例,对照组(帕罗西汀)100例,治疗6周。采用汉密尔顿焦虑量表(HAMA)、临床总体评价量表(CGI)评定临床疗效,采用需要处理的不良反应量表(TESS)评定安全性。结果两组患者的总有效率分别为87.8%和75.5%,差异有显著性(P<0.05),且研究组的起效时间早于对照组。研究组2、4、6周时HAMA减分率均高于对照组,并有显著性差异(P<0.01)。研究组头痛、心动过速、震颤等的不良反应较对照组少而轻。结论帕罗西汀联合普萘洛尔治疗对广泛性焦虑症具有良好的疗效和安全性,且疗效和安全性优于单独应用帕罗西汀。

Objective To observe the clinical effect and adverse effect of paroxetine and propranolol in the treatment of generalized anxiety. Methods Totally 205 patients were randomly divided as trial group （ paroxetine plus propranolol, n = 105） and control group （paroxetine, n = 100）, the treatment for each was six weeks. Hamilton Anxiety Rating Scale （HAMA） and Clinical Global Impression （CGI） were taken to evaluate clinical effect, and the safety was assessed by Treatment Emergent Symptoms Scale （TESS）. Results The total effective rates of the trial group and the control group were 87. 8% and 75.5% respectively, with a significant difference between two groups （ P 〈 0. 05 ） ; and the effect - starting time in the trial group was earlier than that in the control group. The reducing rates in HAMA and HAMD in the trial group were significantly higher than those in the control group at 2, 4, 6weeks （ P 〈0. 01）. The adverse effects such as headache, tachycardia, and tremor in the trial group were less and lighter than those in the control group. Conclusion Paroxetine plus propranolol has good efficacy and safety in treating generalized anxiety, which is better than paroxetine used only.