2型糖尿病患者血清脂联素水平与糖尿病肾病的关系

Relationship Between Serum Adiponectin Concentration and Diabetic Nephropathy in Patients with Type2 Diabetes Mellitus

目的:研究2型糖尿病肾病患者血清脂联素水平与糖尿病肾病的关系。方法:用放射免疫分析测定163例2型糖尿病患者及50例正常人的血清脂联素水平。结果:在糖尿病各亚组中,大量蛋白尿组患者的血清脂联素水平高于微量蛋白尿组(P<0.01)及正常蛋白尿组和对照组(P<0.001)。微量蛋白尿组患者的血清脂联素水平高于正常蛋白尿组(P<0.05)。脂联素水平与血肌酐、HbA1c、TC、SBP、DBP、TG及UAER呈正相关(P<0.05),而与年龄、HDL-C、BMI无明显相关性(P>0.05)。女性血清脂联素水平(15.82±7.21)mg/L高于男性(13.98±7.86)mg/L,但无统计学意义(P>0.05)。结论:2型糖尿病肾病患者血清脂联素水平随着肾病进展而升高,说明肾脏参与了脂联素的代谢与排泄。脂联素在糖尿病肾病发生发展过程中可能起到重要作用。

Objective To investigate the relationship between serum adiponectin concentration and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods The serum adiponectin concentrations were measured with RIA in 163 patients with type2 diabetes mellitus and 50 controls. Results In the diabetic patients, serum adiponectin concentrations were significantly higher in patients with macroalbuminuria （n =54） than those in patients with microalbuminuria （n =57） （P 〈0.01 ）, normal albuminuria （n = 52） and controls （P 〈 0. 001 ）. Adiponectin concentrations were higher in patients with microalbuminuria than in patients with normal albuminuria （ P 〈 0.05 ）. Serum adiponectin concentrations were significantly positively correlated with serum creatinine, HbAlc, TC, SBP, DBP, TG and UAER levels （P 〈 0.05 ）, and adiponectin concentrations were not obviously correlated with age, HDL - C levels and BMI （ P 〉 0.05 ）. Adiponectin concentrations were higher in women than in men, but there was no significant difference （P 〉0.05 ）. Conclusion Serum adiponectin concentrations are increased in type 2 diabetic patients with advanced nephropathy. The kidney seems to be involved in the metabolism and excretion of adiponectin. Adiponectin may play important roles in the onset and development of diabetic nephropathy.