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补肝散对亚急性衰老模型小鼠SOD及MDA的影响

Effect of Reinforcing Liver Powder on SOD and MDA of Subac.Senile Model Mice
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摘要 目的:观察补肝散对D—半乳糖(D-gal)衰老模型小鼠的心肝脑组织超氧化物歧化酶(SOD)活力以及丙二醛(MDA)含量的影响。方法:48只小鼠分为6组,除正常对照组外,其余5组用5%D-gal100mg/kg注射于小鼠颈背部皮下,建立小鼠衰老模型。于造模第43天停止造模用药,正常对照组、自然恢复组用同体积蒸馏水灌胃。补肝散3个给药组分别按12.9g/(kg.d)、25.7g/(kg.d)、51.4g/(kg.d)给药(容积为0.54ml),连续灌胃2周。结果:与正常对照组相比,模型组小鼠心肝脑组织MDA含量明显增加,SOD活力下降,与模型组相比,3个给药组小鼠心肝脑MDA含量明显减少(P<0.05)、SOD活力增强(P<0.05)。结论:补肝散能拮抗自由基损伤,减少D-gal衰老模型小鼠心肝脑组织MDA含量,增强其心肝脑组织SOD活力。 Objective: To observe the effect of Reinforcing Liver Powder on Vital force of SOD and content of MDA in heart, liver and brain tissue of D-gal senile model mice. method: 48 mice were divided into 6 groups. Except the normal control group, 5 groups were injected 5% D-gal 100 mg/kg at the nape subcutaneouly to found the senile model mice. After 43 days, medicine for founding model was stopped. The normal control group and the normal recovery group were in intragastric administration with the same volume distilled water while the three medication administration groups were treated with 12.9g/(kg · d), 25.7g/(kg ·d) and 51.4g/(kg · d) Reinforcing Liver Powder seperately. The time of intragastric administration was 2 weeks. Result : Compared with the normal control group, the content of MDA increases obviously and the vital force of SOD decreases in heart, liver and brain tissue of the model group. Compared with the model group, the content of MDA decreases obviously (P〈0.05) and the vital force of SOD increases (P〈0. 05) in heart, liver and brain tissue of th.e three medication administration groups. Conclusion. Reinforcing Liver Powder has rivalry to free radical injury, decreases the content of MDA and increases the vital force of SOD in heart, liver and brain tissue of D-gal senile model mice.
机构地区 成都中医药大学
出处 《实用中医药杂志》 2007年第4期207-209,共3页 Journal of Practical Traditional Chinese Medicine
关键词 补肝散 小鼠 衰老模型 超氧化物歧化酶 丙二醛 实验研究 Reinforcing Liver Powder mouse senile model SOD MDA empirical study
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