缺氧诱导因子-2α在非小细胞肺癌组织中的表达及其意义

Expression and significance of HIF-2α in non small cell Lung cancer tissues

目的研究缺氧诱导因子-2α(HIF-2α)在非小细胞肺癌(NSCLC)组织中的表达及与肿瘤生物学特征的关系。方法免疫组织化学方法检测NSCLC组织HIF-2α的表达。结果NSCLC组织中HIF-2α阳性表达率为70.8%,显著高于正常肺组织(P<0.05);有淋巴结转移的HIF-2α阳性表达率为73.3%,无淋巴结转移的HIF-2α阳性表达率为66.7%,两者差异具有显著性意义(P<0.05);Ⅰ～Ⅱ期HIF-2α阳性表达率为58.6%,Ⅲ～Ⅳ期HIF-2α阳性表达率为89.5%,两者差异具有显著性意义(P<0.05)。结论HIF-2α的表达与NSCLC的浸润性发展有密切关系。

Objective To investigate the relationship between the HIF-2α expression and tumor biological characteristics in non small celllung cancer （NSCLC）. Methods The expression of HIF-2α in NSCLC tissues was evaluated by immunohistochemical method. Results The positive rate of HIF-2α expression in NSCLC was 70. 8%, and significantly higher than that in normal lung tissues（P〈0. 05）. There was a significant correlation between HIF-2α expression and tumor lymph node metastasis, tumor differentiation, and TNM stages, but no significant correlation was found between H IF-2α expression and tumor pathological type. Conclusion The results suggested that the expression of HIF-2α correlates closely with the metastasis and invasion of NSCLC.