高血压性脑出血高热患者血清CORT、LPO、SOD水平变化及意义

Serum CORT,SOD and LPO level changes and their significance in patients with hypertension intracerebral hemorrhage complicated with hyperthermia

目的探讨高血压性脑出血(HIH)高热患者血清皮质醇(CORT)、脂质过氧化物(LPO)、超氧化物岐化酶(SOD)水平变化及对HIH高热患者预后的影响。方法分别采用放射免疫法、羟胺氧化法、丙二醛法测定42例体温38～38.9℃者(A组)、31例体温39～39.9℃者(B组)、30例体温≥40℃者(C组)入院第2天及高热后第2天血清中CORT、LPO、SOD水平,并与30例健康体检者(D组)作对照。同时对A、B、C三组预后生活质量进行比较。结果A、B、C三组入院第2天血清CORT、SOD、LPO比较无显著性差异(P>0.05),但均明显高于D组(P<0.01);高热第2天A、B、C三组血清CORT、LPO含量较入院第2天均明显升高(P<0.05,P<0.01),SOD显著降低(P<0.05,P<0.01);B组较A、C组高热第2天血清中CORT、LPO含量明显升高或降低(P<0.05),SOD降低或升高(P<0.05)。A、B、C三组预后神经功能缺损程度评分、日常生活能力评分比较有显著性差异(P<0.05)。结论HIH患者早期血清中CORT、LPO水平明显升高,SOD显著降低;高热时体温越高CORT、LPO水平越高,SOD越显著降低;CORT、LPO越升高,对HIH患者的预后生活质量影响越大。

Objective To study level changes of serum CORT, SOD and LPO in hyperthermia patients with hypertension intracerebral hemorrhage （HIH） and to observe the potential effects on survival prognosis. Methods All the cases were divided into three groups （A group：n=42,T：38-38.9℃;B group： n=31,T：39-39.9cC;C group： n=30,T≥40℃）. By using the methods of radioimmunoassay hydroxylamine oxidation and thirddialdehyde, the serum CORT, SOD and LPO levels were measured on the 2nd day after hospitalization and hyperthermia respectively; and compared to that of heatlhy volunteers （D group,n=30）, in addition, the NDS,ADS of survival prognosis were compared among three groups. Results There were no significant differences in the serum levels of CORT, SOD and LPO among A,B,C groups on the 2nd day after hospitalization （P〉0.05） but it was higher than D group. The serum CORT, LPO levels were higher on the 2nd day after hyperthermia than hospitalization（P〈0.05,P〈0.01）; while SOD was adverse （P〈 0.05,P〈0.01）. The serum level of CORT, LPO in B group were higher or lower than A and C groups on the 2nd day after hyperthermia （P〈0.05）, the SOD was adverse （P〈0.05）. The NDS,ADS of survival prognosis had distinct difference among three groups （P〈0.05）. Conclusion The serum levels of CORT, LPO are higher and SOD is lower in early patients with HIH. The higher the body temperature of patients is, the higher the serum CORT, LPO levels are, the lower SOD was in hyperthermia patients with HIH. Thus survival prognosis is related with serum CORT, LPO levels in hyperthermia patients with HIH.