心房颤动中C反应蛋白增高的临床意义

The Clinical Significance of Elevated C-reactive Protein in Patients with Atrial Fibrillation

目的:探讨C反应蛋白(CRP)增高在心房颤动(房颤)中的意义。方法:应用免疫法测定76例诊断为房颤患者(房颤组)血清CRP水平,与非房颤患者(对照组)28例比较;并对房颤按时间、病因不同分设组,进行统计学分析。结果:房颤组血清CRP为(4.31±2.88)mg/L,明显高于对照组的(1.15±0.91)mg/L,P<0.05。器质性、孤立性房颤者CRP分别为(5.05±1.91)mg/L,(4.37±1.32)mg/L;持续性、永久性房颤患者CRP分别为(5.60±1.81)mg/L,(5.05±1.59)mg/L,均高于阵发性房颤者的(3.30±1.20)mg/L,P<0.05。结论:CRP增高反映的炎症状态可能促进房颤发生和呈持续性发作。

Objective： To evaluated the effect of CRP increasing in pathogenesis of atrial fibrillation （AF）. Methods： The immunochemistry method was used to determine the serum CRP concentration in 76 AF cases. Grouping these patients according to the lasting paroxysm of AF and pathogenetic factor. Results： Serum CRP of patients with AF （4.31±2.88） mg/L was higher than that in control group （1.15±0.91）mg/mL, P 〈 0.05. The CRP of nonfunctional and isolated AF cases were （5.05±1.91） mg/L and （4.37±1.32） mg/L. Serum CRP of persistent and permanent AF patient were （5.60±1.81） mg/L and （5.05±1.59） mg/L respectively, higher than in paroxysmal AF （3.30±l.20）mg/mL, P 〈 0.05. Conclusion： The inflammatory state, reflected by the elevation of serum CRP level, may promote the occurance and persistence of AF.