锰的神经毒性机制与基因调控

Study on neurotoxic mechanism of manganese and the gene regulations

长期高剂量的锰暴露,可出现类似帕金森综合征的锥体外系神经损害。大量研究证明,锰可选择性的使多巴胺能神经细胞凋亡,而细胞凋亡过程需要多种基因的调控,本文将近年来从基因调控水平上探讨锰神经毒性机制的研究综述如下。

The long term and high level exposure to manganese might induce Parkinson＇s disease-hke extracorticospinal tract damage in nervous system. Many studies have demonstrated that manganese could selectively make dopamine-energy neuron cell apoptosed, which is such a process needed a lot of gene regulations. This article will summarize the papers concerned the neurotoxic mechanism of manganese on the level of gene regulation and control in recent years.