特利加压素在脓毒血症难治性休克中的应用价值

目的旨在探讨特利加压素(Terlipressin)对脓毒血症难治性休克的临床应用价值。方法对12例经多巴胺、去甲肾上腺素治疗无效的脓毒血症休克患者改用特利加压素2μg/(kg·h),并分别观察用药后6、12、24h心率、平均动脉压、休克指数和尿量变化。结果特利加压素使用6h后平均动脉压明显上升、休克指数明显下降,使用12h后心率、尿量明显改善。结论对严重脓毒血症难治性休克,特利加压素具有一定的临床应用价值。

Objective To evaluate the clinical efficacy of Terlipressin for treatment of intractable septic shock . Methods 12 patients with septic shock were treated with Terlipressin 2ug/kg/h after inefficiency with dopamine and norepinephrine , MAP, HR, shock index number and UV were recorded and compared before and 6,12,24h after the therapy. Results 6h after the administer of Terlipressin, patients＇ MAP rose and shock index number reduced dramatically , 12h after treatment by Terlipressin , patients＇ HR improved significantly （ P 〈 0.01 ）. Conclusion Terlipressin have clinical therapeutic effects for intractable septic shock.