血清S100b蛋白在新生儿缺氧缺血性脑病早期含量变化及其临床意义

Early changes and clinical significance of serum S100b protein with Hypoxic-ischemic Encephalopathy

目的:探讨血清S100b蛋白对新生儿缺氧缺血性脑病(HIE)早期诊断的临床意义。方法:检测65例HIE患儿在出生后24h、72h血清S100b蛋白的含量,并与同期50例正常新生儿血清S100b蛋白含量相比较。结果:HIE组在出生24h、72h血清S100b蛋白含量明显高于对照组,差异有显著意义(P<0.01);轻度HIE组与中度HIE组在出生24h、72h血清S100b蛋白含量差异有显著意义(P<0.01),中度HIE组与重度HIE组在出生24h、72h血清S100b蛋白含量差异有显著意义(P<0.01),血清S100b蛋白含量与HIE脑损伤程度呈正相关。结论:早期检测HIE患儿血清中S100b蛋白含量对HIE早期诊断及病情程度判定具有一定应用价值。

Objective ：To explove the clinical significance of serum S100b protein on newborns with Hypoxic -ischemic Encepha lopathy （HIE） in early diagnosis. Methods：Content of serum S100b protein of 65 HIE infants 24 hours and 72hours after birth was measured, and compared to 50 normal newborns. Results ：Content of serum s100b protein of the HIE group 24 hours and 72 hours ofter birth was significantly higher than the content of the control group and difference was significant （ P 〈 0.01 ）. The difference of content of serum S100b protein was significant between the mild. HIE group and the mederate HIE group（ P 〈 0.01 ）. The difference of content of serum S100b protein was sigllificant between the moderate HIE group and the serious HIE group（ P 〈 0.01 ）. The content of serum S100b protein was positive eorrelations with HIE severity of brain damage. Conclusions：Early measure of the content of serum S100b protein of HIE infants had eertain clinical value to the early diagnosis of HIE and the severity of illness＇s determination.