多囊性肾细胞癌临床病理诊断

Clinicopathologic diagnosis of multilocular cystic renal cell carcinoma

目的:研究多囊性肾细胞癌的病理形态学特征及鉴别诊断。方法:对2例多囊性肾细胞癌进行光镜观察及免疫组化标记,并进行文献复习。结果:肿瘤由厚的假纤维包膜围绕,切面见大小不等的囊腔。镜下见囊腔上皮为无明显异性的透明细胞,纤维性囊壁中可见透明细胞巢。癌细胞免疫表型CK、EMA、Vimentin阳性,CD68阴性,P53弱阳性。结论:多囊性肾细胞癌是一种罕见的肾癌类型,是一种低度恶性潜能肿瘤。术前易与肾细胞癌伴囊性变、多囊肾、节段性囊性疾病、囊性肾瘤等混淆。

Objective ：To study the pathomorphologic features and the diagnostic method of multilocular cystic renal cell carchionia （MCRCC）. Methods：2 case of MCRCC were examined by light microscopy and immunohistochemical staining. The result was compared with the lierature. Results：The tumors were surrounded by fibrous pseudocapsule. Cross -sectioning showed cysts of various sizes. The septa contained aggregates of epithelial cells with transparent cytoplasm. The majority of carcinoma ceils were CK, EMA, Vimentin positive, p53 weak positive and CD68 negative by immunohistochemical staining. Conclusion： MCRCC is a rare histological subtype of renal ceil carcinoma. It is a tumor with low degree of malignancy. Berore operation, it is easily confused with renal cell carcinoma with cystic formation, multicapsular cystic kidney , segmental cystic diseases and cystic nephroma.