摘要
随着高分辨核磁共振扫描仪及其相应软件的发展和应用,核磁共振频谱的研究范围越来越广泛,磁共振频谱为长期以来各种研究方法未能较好的在活体水平解决的细胞凋亡的代谢物变化问题提供了较新的无创的可重复的可靠的方法。本文就细胞凋亡发生过程中的生化代谢及病理改变,现阶段核磁共振频谱在细胞凋亡中的研究成果和存在问题及其在临床的应用前景,做一综述。
出处
《赣南医学院学报》
2007年第1期155-157,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
参考文献19
-
1Michael T.Crow,Kartik Mani,Young-Jae Nam,et al.The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis[J].Circulation Research,2004,95:957.
-
2John C,Reed and Maurizio,Pellecchia,et al.Apoptosis-based therapies for hematologic malignancies,The American Society of Hematology[J].BLOOD,2005,106(2):408-418.
-
3Yun-Ping Zhou,Deeling Teng,Flora Dralyuk,et al.Apoptosis in Insulin-secreting Cells Evidence for the Role of Intracellular Ca^2+ Stores and Arachidonic Acid[J].J.Clin.Invest,1998,101:1623-1632.
-
4Sankhavaram R,Paninia,Lin Yanga,et al.Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol[J].Journal of Lipid Research,2001,42:1678-1686.
-
5Armin foghi,Amir ravandi,Katja J,et al.Fas-Induced Apoptosis in Rat The cal/Interstitial Cells Signals Through Sphingomyelin-Ceramide Pathway[J].Endocrinology,139(4):2041-2047.
-
6Kjetil Berge,Karl Johan Tronstad,Pavol Bohov,et al.Impact of mitochondrial β-oxidation in fatty acid-mediated inhibition of glioma cell proliferation[J].Journal of Lipid Research,2003,44:119-127.
-
7Anna J.Kim1.Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3[J].Journal of Cell Science,2005,118 (1):89-99.
-
8Francis G.Blankenberg,Richard W.Storrs,Louie Naumovski,et al.Detection of Apoptotic Cell Death by Proton Nuclear Magnetic Resonance Spectroscopy[J].Blood,1996,87(5):1951-1956.
-
9Francis G.Blankenberg,Peter D.Katsikis,Richard W.Storrs,et al.Quantitative Analysis of Apoptotic Cell Death Using Proton Nuclear Magnetic Resonance Spectroscopy,American Society of Hematology[J].Blood,1997,89(10):3778-3786.
-
10Chwen-Ming Shih,Wun-Chang ko,Liang-yo yang,et al.Detection of Apoptosis and Necrosis in Normal Human Lung Cells Using 1H NMR Spectroscopy[J].New York Academy of Sciences,2005,1042:488-496.
同被引文献20
-
1Rosen Y,Lenki RE.Recent Advances in Magnetic Resonance Neurospectroscopy[J].Neurotherapeutics,2007,4(3):330-345.
-
2Valenzuela MJ,Sachdev P.Magnetic resonance spectroscopy in AD[J].Neurology,2001,56:592-598.
-
3Lin A,Ross BD,Harris K,et al.Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making[J].NeuroRx,2005,2(2):197 -214.
-
4Doelken MT,Mennecke A,Stadlbauer A,et al.Multi-voxel Magnetic Resonance Spectroscopy of Cerebral Metabolitesin Healthy Adults at 3 Tesla[J].Acad Radiol,2009,16:1493-1501.
-
5Lin AP,Ross BD.Short echo time proton Mrspectroscopyin the presence of gadolinium[J].Jcomput Assist Tomogr,2001,25(5):705 -712.
-
6Marshall I,Wardlaw J,Graham C,et al.Repeat-ability of long and short echo-time in vivo proton chemical shift imaging[J].Neuroradiology,2002,44:973-980.
-
7Yongbi NM,Payne GS,Collins DJ,et al.Quanti cation of signal selection ef ciency,extra volume suppression and contamination for ISIS,STEAM and PRESS localized 1HNMR spectroscopy using an EEC localization test object[J].Phys Med Biol,1995,40:1293-1303.
-
8Provencher SW.Automatic quantitation of localized in vivo 1 H-spectra with LCModel[J].NMR Biomed,2001,14:260-264.
-
9Jiru F,Dezortova M,Burian M,et al.The role of relaxation time corrections for the evaluation of long and short echot ime 1H-MR spectra of the hippocampus by NUMARIS and LCModel techniques[J].Magma,2003,16(3):135-143.
-
10Mucke L.Neuroscience:Alzheimer' s disease[J].Nature,2009,461:895-897.
-
1姚建莉,曹震,吴仁华.氢质子磁共振频谱在阿尔茨海默病的应用研究进展[J].汕头大学医学院学报,2009,22(4):247-250. 被引量:1
-
2马郴生.有关医院病人营养代谢变化问题[J].实用护理杂志,1994,10(7):37-38. 被引量:1
-
3郝文静.MRI在女性盆腔肿块诊断中的价值研究[J].基层医学论坛,2015,19(2):220-222. 被引量:2
-
4张苗苗,吴仁华.核磁共振频谱对探测凋亡细胞代谢物变化的研究[J].功能与分子医学影像学(电子版),2013,2(2):53-56.
-
5杨振华.常见酶测定的临床应用——医学检验与临床(9)[J].新医学,1993,24(3):160-162. 被引量:4
-
6张奇,黄刚,刘曼芳.核磁共振扫描室照明系统的设计[J].医疗设备信息,1999(2):65-65.
-
7李春光,崔刚,朴龙洽.电疗法中有关pH变化问题的研究[J].延边医学院学报,1994,17(2):107-109.
-
8阮正敏,赵斌.磁共振波谱技术在乳腺癌诊断中的应用[J].医学影像学杂志,2006,16(12):1302-1304.
-
9张靖华,马健飞.NO在CAPD及其相关性腹膜炎中的作用[J].日本医学介绍,2005,26(9):424-426.
-
10刘素品.急性心肌梗死患者26例的护理体会[J].中国社区医师(医学专业),2012,14(17):353-353.