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20-羟二十烷四烯酸在机体生理及病理调节中的作用 被引量：5

Roles of 20-HETE on Physiologic and Pathologic Regulation in Organism
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摘要 20多年前,国外学者就报道了机体内某些组织中存在着细胞色素P-450(cytochrome P-450,CYP)。已经证实它能催化花生四烯酸(arachidonic acid,AA)的ω-羟基生成20-羟二十烷四烯酸(20-hydroxyeicosatetraenoic acid,20-HETE)。随着研究的不断深入,人们逐渐发现作为第二信使,20-HETE在调节血管平滑肌紧张度、肾功能、脑血流量和肺血管舒张过程中发挥了重要作用;外源性的20-HETE对心脏冠脉循环也有明显的调节作用;并且它与高血压和妊娠毒血症等疾病的发生和发展关系密切。但国内对于20-HETE的相关研究还鲜有报道,本文将主要就20-HETE在机体生理及病理调节中的作用作一综述。 Twenty years ago, some foreign-investigators reported that ω-hydroxylation of arachidonic acid （AA） was catalyzed by cytochrome P-450 enzymes in some tissue to 20-hydroxyeicosatetraenoic acid （20-HETE）. As a second messenger, it plays a pivotal role in the regulation of vascular tone, renal function, cerebral blood flow and lung vasodilator. Exogenous administeration of 20-HETE also plays an important role in the regulation of the coronary circulation. Moreover, hypertension, toxemia of pregnancy and other diseases is related to the formation of the 20-HETE. However, there is few domestic report about 20-HETE. Therefore, the domestic investigators should be given attention to 20-HETE adequately in the future. In this paper,roles of 20-HETE on physiologic and pathologic regulation in organism were reviewed.
作者 张迪 霍洪亮 张英妮 曾庆华
机构地区 东北师范大学生命科学学院生理研究室
出处 《生理科学进展》 CAS CSCD 北大核心 2007年第2期120-124,共5页 Progress in Physiological Sciences
关键词 20-HETE 花生四烯酸 细胞色素P-450 第二信使 20-HETE arachidonic acid cytochrome P-450 second messenger
分类号 Q46 [生物学—生理学] R363 [医药卫生—病理学]
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参考文献19

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二级参考文献8

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生理科学进展
2007年 第2期

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