984株结核分枝杆菌耐药情况分析

Analyzing 984 drug resistant M. Tuberculosis

目的了解浙江省当前结核病对一线抗结核药物的耐药水平及耐多药情况,为今后结核病防治工作提供参考依据。方法采用WHO推荐的药敏比例法对984株临床分离结核分枝杆菌进行药物敏感性试验。结果总耐药率为30.6%,初始耐药率为26.6%,获得性耐药率为52.3%,耐多药(MDR)率为7.6%。结论浙江省耐药水平有上升趋势,应引起相关卫生部门的关注。

Objective To understand the levels of drug resistance and multi-drug resistance for the firstline anti-tubeculoais drugs in Zhejiang province, and to provide evidence for tuberculosis control. Methods The proportional method was used in drug sensitivity test according to the guidelines recommending by WHO. Results The total drug resistance rate was 30.6 %, the initial and the acquired drug resistance rate was 26.6 % and 52.3% respectively, and the multi-drug resistance rate was 7.6%. Conclusion The tuberculosis drug resistance was increasing in Zhejiang province, and the tuberculosis control departments should pay more attention to this situation.