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Platelet-Leukocyte Interaction and Thrombosis 被引量:1

Platelet-Leukocyte Interaction and Thrombosis
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摘要 Cerebrocardiac thrombotic disease such as acute my-ocardial infarction and acute ischemic stroke cause significant morbidity and mortality. Present therapies for these diseases besides anttcoagulation and fibrinolysis mainly aim toward limiting platelet adhesion and aggregation processes. However, their incomplete effectiveness suggests that other mechanisms may be important. Although the underlying cellular and molecular mechanisms Cerebrocardiac thrombotic disease such as acute myocardial infarction and acute ischemic stroke cause significant morbidity and mortality. Present therapies for these diseases besides anttcoagulation and fibrinolysis mainly aim toward limiting platelet adhesion and aggregation processes. However, their incomplete effectiveness suggests that other mechanisms may be important. Although the underlying cellular and molecular mechanisms of pathogenesis are complex, an early event in vessel injury is the adhesion of platelets and leukocytes to the damaged arterial wall. Recent studies havedemonstrated that the patients with acute coronary syndrome and ischemic stroke have not only increased interaction between platelets( homotypic aggregates) but also increased interaction between platelets and leukocytes(heterotypic aggregates) detectable in circulating blood, and that the heterotypic aggregation contribute significantly to these disease progression.
出处 《血栓与止血学》 2007年第2期51-52,共2页 Chinese Journal of Thrombosis and Hemostasis
关键词 血小板 白细胞 血栓症 急性冠状综合症 交互作用 Platelet Leukocyte Thrombosis Acute coronary syndrome Stroke
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