阿片强化作用的神经化学机制

Neurochemical mechanisms of opiate reinforcement

目的综述阿片强化的神经化学机制。方法在查阅和总结28篇国内外相关文献的基础上,着重论述了与阿片强化作用密切相关的神经递质系统及其相互关系。结果和结论阿片强化作用的产生与中脑边缘多巴胺能系统密切相关。此外,腹侧背盖区和伏隔核等部位的γ-氨基丁酸及其它非多巴胺能神经递质系统在阿片强化作用中也起到重要作用。

Objective To review the neurochemical substrates of opiate reinforcement. Methods The related papers were consulted and the neurochemical mechanisms of opiate reinforcement were reviewed. Results and conclusions Dopamine and non-dopamine substrates, including opiate, Gamma-aminobutyric acid （GABA）, glutamate and serotonin are well involved in the opiate reinforcement. The activities of dopamine and GABA ergic neurons in the ventral tegmental area and the nucleus accumbens play critical roles.