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用胶束液相色谱模拟生物膜预测药物的醇-水分配系数log P 被引量:3

Prediction of Octanol-Water Partition Coefficients (log P) of Drugs by Micellar Liquid Chromatography Simulating Biomembrane
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摘要 通过比较药物在不同类型表面活性剂的胶束液相色谱中的容量因子与药物的醇-水分配系数(log P)的相关性,发现药物在非离子型表面活性剂Brij35作为流动相的胶束液相色谱中的容量因子与其文献中报道的log P间有一定的相关性,进一步考察了Brij35浓度对药物保留的影响,并建立了药物在不同浓度的Brij35胶束液相色谱中的容量因子与文献中log P的相关关系,该方法简单、快速,将为药物的疏水性评价提供重要的参考价值。 Brij35 micellar liquid chromatography (MLC) was presented for prediction of the octanol-water partition coefficient (log P) of drugs by comparing the retention factors of drugs in different surfactants with log P in literature. The results showed that the retention factors of drugs in Brij35 MLC were related with log P of drugs in literature. The effect of Brij35 concentration on the retention of drugs was studied and the relationship was established between the retention factors of drugs in surfactant of different concentration and log P. This method is simple, rapid and can provide valuable reference information for hydrophobicity of drugs.
出处 《化学学报》 SCIE CAS CSCD 北大核心 2007年第8期693-698,共6页 Acta Chimica Sinica
关键词 胶束液相色谱 Brij35表面活性剂 醇-水分配系数log P micellar liquid chromatography surfactant Brij35 octanol-water partition coefficient log P
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参考文献8

  • 1OECD Guideline to Test Chemical Products 107,Partition Coefficient (n-Octanol/Water),Shake Flask Method,OECD,Paris,France,1981.
  • 2Molero-Monfort,M.; Escuder-Gilabert,L.; VillanuevaCamanas,R.M.; Sagrado,S.; Medina-Hernandez,M.J.J.Chromatogr.B 2001,753,225.
  • 3Escuder-Gilabert,L.; Martínez-Pla,J.J.; Sagrado,S.;Villanueva-Camanas,R.M.; Medina-Hernández,M.J.J.Chromatogr.B 2003,797,21.
  • 4Escuder-Gilabert,L.; Mart'in-Biosca,Y.; Sagrado,S.;Villanueva-Camanas,R.M.; Medina-Hernández,M.J.Anal.Chim.Acta 2001,448,173.
  • 5Bermúdez-Saldana,J.M.; Escuder-Gilabert,L.; MedinaHernández,M.J.; Villanueva-Camanas,R.M.; Sagrado,S.J.Chromatogr.B 2005,814,115.
  • 6Berm'udez-Salda~naa,J.M.; Garciab,M.A.; MedinaHern'andeza,M.J.; Marinab,M.L.J Chromatogr.A 2004,1052,171.
  • 7Bermúdez-Saldana,J.M.; Escuder-Gilabert,L.; MedinaHernández,M.J.; Villanueva-Camanas,R.M.; Sagrado,S.J.Chromatogr.A 2005,1063,153.
  • 8毛晶晶,孙进,李洁,高坤,何仲贵.阴离子型胶束液相色谱的溶质保留行为[J].分析化学,2005,33(9):1247-1251. 被引量:7

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