红花籽油和邦贝抗炎栓对宫颈糜烂大鼠免疫功能影响的对比研究

THE COMPARISON STUDY OF SAFFLOWER OIL AND BANGBEIKANGYANSHUAN ON IMMUNE FUNCTION IN ANIMAL MODEL

目的探讨红花籽油、邦贝抗炎栓对宫颈糜烂大鼠免疫功能的影响。方法48只雌性大鼠随机分为正常对照组、模型对照组、邦贝抗炎栓组、邦贝去红花籽油组、红花籽油组、双唑泰组(阳性对照组)。除正常组外,其余组均用苯酚行阴道注射建立大鼠宫颈糜烂模型。药物治疗12天后,断头采血制备血清,用酶链免疫法测定血清IL-1、TNF-α含量。结果模型对照组与正常对照组对比,血清IL-1、TNF-α水平明显增高,而邦贝抗炎栓组、红花籽油组、双唑泰组的IL-1、TNF-α水平显著下降,与模型对照组相比,结果分别显示显著性差异;邦贝抗炎栓组和红花籽油组间IL-1、TNF-α水平也有差异。结论邦贝抗炎栓和红花籽油都能调节宫颈糜烂大鼠的免疫功能,这可能是其治疗宫颈糜烂的机制之一;复方邦贝抗炎栓疗效更优于单味药红花籽油。

Objective To with cervical erosion. Methods explore the effects of Bangbeikangy 48 healthy SD rats were ranomly anshuan（BB） and safflower oil（SO） on the rats divided into control group, model group, BB group, SO group, BBQ（Bangbeiquhonghua） group and SZT（Shuangzuotai） group. Distinct menicine was used to treat the groups rats modeled by Benfenjiaojiang. The IL - 1 and TNF-α of mice of cervical mucosa wered observed. Results The group which pretreated with SO and BB compered with the model group, the IL - 1 and TNF -α were signficanly lower in rats （ P 〈 0. 05 ） Conlusion So and BB are an effective medicines, they can reduce the degree of IL - 1 and TNF-α, and BB is better than SO.