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髓鞘碱性蛋白的临床应用 被引量：9

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摘要 髓鞘碱性蛋白（myelinbasicprotein，MBP）是脊椎动物中枢神经系统少突细胞和周围神经系统雪旺细胞合成的一种强碱性膜蛋白．含有多种碱性氨基酸。1962年，Laatsch等首先从豚鼠脑中分离出MBP．随后国内外学者对MBP进行了广泛和深入的研究．试图阐明人类脱髓鞘疾病的发病原理，寻找诊断和治疗方法。国外还用直接合成多肽的方法合成MBP的某一肽段，用于检测和治疗中枢神经系统疾病。同时，患者的MBP可释放到脑脊液或血液中，可作为判断中枢神经系统破坏程度的指标，对判断病情严重程度和预后有重要意义。
作者 宋翠荣 刘皓
机构地区 天津医科大学组织胚胎学教研室
出处 《天津医科大学学报》 2007年第1期115-117,121,共4页 Journal of Tianjin Medical University
基金 国家自然科学基金重点资助项目(30230330)
关键词 髓鞘碱性蛋白 中枢神经系统 多肽
分类号 Q7 [生物学—分子生物学] R741 [医药卫生—神经病学与精神病学]
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参考文献21

  • 1Harauz G, Ishiyama N, Hill CM, et al. Myelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis [J]. Micron, 2004,35(7):502.
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  • 3Lamers KJ,Vos P, Verbeek MM,et al. Protein S-lO0.neuron-specific enolase(NSE).Myelin basic protein (MBP)in cerebrospinal fluid(CSF) and blood of neurological patients [J]. Brain Res Bull, 2003,6(3):261.
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  • 7陈俊,何国厚,黎华,余绍祖.急性脑梗死患者髓鞘碱性蛋白动态检测的临床意义[J].郧阳医学院学报,2005,24(2):77-79. 被引量：6
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二级参考文献22

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天津医科大学学报
2007年 第1期

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