武汉地区人群弓形虫感染血清学调查分析

The serological survy of Toxoplasma infection in Wuhan city

目的了解武汉市弓形虫感染现状,为制定防治策略提供科学依据。方法采用酶联免疫吸附试验(ELISA)方法,检测人群血清弓形虫IgG抗体。结果共检测3009人,阳性141人,平均阳性率4.69%。其中特殊人群(兽医、饲养员、肉贩、宠物猫犬主、孕妇、献血员等)阳性率6.51%(117/1798),一般人群(对照组)阳性率1.98%(24/1211),有非常显著意义差异(P<0.01)。不同地区、性别、民族以及文化程度之间差异无显著性意义(P>0.05)。结论弓形虫血清学阳性率与接触感染动物的机会密切相关,兽医、饲养员、肉贩等是弓形虫感染的高危人群;本次调查孕妇与献血员弓形虫阳性率高于一般人群,应引起重视,建议加强血清学监测,便于及时采取有效干预措施。

This study aimed to the present situation of Toxoplasma infection in Wuhan, Hubei province, so as to supply the scientific evidence for the strategy of treatment and prevention. The ELISA assay was used to determine the concentration of IgG of Toxoplasma in blood serum of the persons. Total 3 009 persons were determined, 141 of whom were positive and the total positive rate was 4.69%. Among these, the positive rate in special population（veterinarians, stockmen, meat-sellers, owners of pet dogs or cats, pregnant women, blood donors） was 6.51% （117/1 798）, and the one of ordinary crowds （control group） was 1.98% （24/1 211）. The difference between the two kinds of crowds was very significant （P 〈0.01）. There were no significant differences among different districts, sexualities, nations, and cultural degree. These results suggested that the serology positive rate of the persons was highly related to the time the perosons toughing the infected animals. The veterinarians, stockmen, meat sellers, and the owners of pet dogs or cats were the high-risk group. In this study, the positive rate of pregnant women and blood donor was higher than the ordinary crowds, which should be payed much attention. It was suggested that serological monitoring should be employed to these crowds, so that effective intervention methods wese used in time.