VEGF-C在宫颈鳞癌组织中的表达及临床意义

The Expressions and Significance of VEGF-C in Cervical Carcinoma

目的检测血管内皮生长因子C(VEGF-C)在正常宫颈、宫颈上皮内瘤变(CIN)及宫颈鳞癌组织中的表达,探讨VEGF-C与宫颈癌发生发展、淋巴结转移的关系。方法采用免疫组织化学S-P法,检测22例正常宫颈上皮、63例CIN、45例宫颈鳞癌组织中VEGF-C的表达。结果VEGF-C在正常宫颈黏膜上皮、CIN及宫颈鳞癌组织中的表达依次增高,三者之间相比,差异有统计学意义(P<0.05)。伴有淋巴结转移的宫颈癌组织中VEGF-C的表达明显高于无淋巴结转移病例(P<0.01)。VEGF-C在低分化鳞癌组织中的表达明显高于中高分化鳞癌组织(P<0.05),但与临床分期无关。结论VEGF-C蛋白表达与宫颈鳞癌发生发展及淋巴转移有关。

Objective To detect the expressions of VEGF-C in normal uterine cervix, cervical intraepithelial neoplasia （CIN） and carcinoma of cervix and to determine its role in the progression and invasion or metastasis of cervical carcinoma. Methods The expressions of VEGF- C in 22 cases with normal uterine cervix tissues, 63 cases with CIN tissues and 45 cases with carcinoma of cervix uteri tissues were detected by immunohistochemical S-P method. Results The expression rates of VEGF-C were gradually increased with the progress cervical lesions. There was significant difference between the two groups（P 〈 0.05 ）. The expression of VEGF-C was higher in cervical cancer with lymphatic metastasis than that without lymphatic metastasis（ P 〈0.01 ）. The expression of VEGF-C in low differentiation group was significantly higher than that in middle/high differentiation groups（P 〈 0.05）. There was no correlation between the expression of VEGF-C and clinical stage. Conclusions The expression of VEGF-C might be involved in oncogenesis or development and lymphatic metastasis in cervical carcinoma.