应用艾恒亚叶酸钙5-氟脲嘧啶方案(FOLFOX4)治疗晚期大肠癌35例疗效观察

An Overview of Curative Effect of Modified FOLFOX4 Regimen in the Treatment of Advanced Colorectal Cancer

目的评价改良的FOLFOX4方案治疗晚期大肠癌的疗效和毒性。方法艾恒（国产奥沙利铂）85mg／m^2静滴2hd1；亚叶酸钙（CF）200mg／m^2静滴2hd1-2，5-氟脲嘧啶（5-Fu）400mg／m^2静脉推注d1-2（或快速静脉滴入），5-Fu600mg／m^2持续静脉滴注（CIV）22hd1-2，每14d为1周期（2周期后进行疗效评价）。结果全组35例患者，总有效率（CR＋PR）为57．14％，中位肿瘤进展时间（TTP）为8．1个月。主要不良反应为随累积剂量增加外周神经感觉异常、口腔黏膜炎、骨髓抑制、恶心呕吐和腹泻，但多为Ⅰ-Ⅱ度。结论改良的FOLFOX4方案治疗晚期大肠癌疗效较高，毒副反应可耐受。

Objective To evaluate the effects and toxicities of modified FOLFOX4 regimen for treating patients with advanced colorectal cancer. Methods OXA 85 mg/m^2 was given intravenously 2 h,d1 ;CF 200 mg/m^2 iv 2 h,d1 -2 , followed by 5-Fu 400 mg/m^2 iv bolus plus 5-Fu 600mg/m^2 iv continuous infusion 22 h, d1-2- Each cycle was in divided doses for a period up to 14 days. Results The overall response rate （ CR ＋ PR） was 48.3% ,and amedian time to progression was 8.1 months. The more side effects following accumulating doses of drugs were commonly seen with mild neuro-sensory toxicity, mucitis suppression of bone marrow ,diarrhea , nausea and vomiting of grade Ⅰ to Ⅱ . Conclusions The modified FOLFOX4 regimen is highly effective and well tolerated in treatment of advanced colorectal cancer.