胰腺癌组织中神经生长因子受体的表达意义

Expressions of nerve growth factor receptors in human pancreatic cancer

目的:研究神经生长因子(NGF)高亲和受体TrkA与低亲和受体p75在胰腺癌中的表达意义.方法:应用实时定量PCR法检测56例胰腺癌组织中TrkA及p75的表达并进行临床病理及预后分析.结果:所有组织标本中均可检测出TrkA及p75的表达呈负相关.p75与TrkA的表达水平与患者的腹背部疼痛和神经浸润程度有关(P均<0.05).Cox单变量分析揭示,高p75表达患者较高TrkA患者的总生存时间延长(P<0.05),Cox多变量分析揭示,p75及TrkA均为影响预后的独立因素.结论:胰腺癌中TrkA的表达促进肿瘤的恶性进展,而p75则相反,NGF刺激增长或抑制胰腺癌的双重作用可能与TrkA及p75的表达比率相关.

AIM： To investigate the prognostic values of 2 nerve growth factor receptors （ NGFR）, high-affinity receptor TrkA and low-affinity receptor p75, in pancreatic cancer. METHODS： We detected the expressions of TrkA and p75 mRNA in 56 cases of primary pancreatic cancer by using real-time quantitative RTPCR. Their clinical manifestations, pathological characteristics and prognosis were analyzed comparatively. RESULTS： TrkA and p75 were both found in all 56 cases of pancreatic cancer. TrkA and p75 levels were correlated with abdominal or back pain and perineural invasion （ P 〈 0. 05 ）. Cox univariate analysis revealed that the cases with higher expression of p75 survived the ones with higher expression of TrkA （ P 〈 0. 05 ） , and Cox multivariate analysis indicated that TrkA and p75 were both the independent factors influencing the prognosis. CONCLUSION： The expression of TrkA in pancreatic cancer is a marker of tumor aggressiveness; conversely, the elevated p75 expression is associated with a favorable prognosis. NGF exerts stimulatory or inhibitory effects on pancreatic cancers, which depends on the expression levels and ratio of TrkA to p75NGFR.