聚腺苷二磷酸核糖聚合酶抑制剂在神经保护方面的研究进展

Research progress of PARP inhibitors on neuro-protection

作者对聚腺苷二磷酸核糖聚合酶[poly(ADP-ribose)polymerase,PARP]的结构亚型和生物学功能做了简要介绍。归纳了近几年PARP抑制剂在神经保护方面的研究成果。并从结构分类的角度探讨了部分具有应用前景的化合物的构效关系。

The poly（ADP-ribose）polymerase（PARP）, a nuclear enzyme relative to DNA repair, is a mediator of cell death by ATP depletion. Thus the PARP inhibitor was considered as a novel neuro-protectant. A study about structure and biological activity of PARP was introduced in this review, and emphasis was placed on both the neuro-protective function and the structure-activity relationship of the PARP inhibitors reported in recent years.