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E-钙黏蛋白和MMP-2在皮肤鳞状细胞癌中的表达及其意义 被引量：2

Expression of E-cadherin and MMP-2 and its significance in cutaneous squamous cell carcinoma
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摘要 目的:探讨E-钙黏蛋白(E-cadherin)和MMP-2在皮肤鳞状细胞癌(CSCC)中的表达及与转移的关系。方法:应用免疫组化SP法检测E-cadherin和MMP-2在10例正常皮肤组织和43例CSCC组织中的表达。结果:43例CSCC中E-cadherin弱表达或无表达者30例(69.8%),其中31例无淋巴结转移的CSCC组织中19例(61.3%)和12例有淋巴结转移的CSCC组织中11例(91.7%);43例CSCC中34例(79.1%)MMP-2呈阳性表达,其中31例无淋巴结转移的CSCC组织中23例(74.2%)和12例有淋巴结转移的CSCC组织中11例(91.7%)。结论:E-cadherin的表达下调和MMP-2的表达上调可能与CSCC的转移有关。 Objective： To determine the expression of E - cadherin and MMP - 2 in cutaneous squamous cell carcinoma（CSCC）and to explore its relationship with metastasis, Methods ： The expressions of E - cadherin and MMP - 2 in specimens from 10 normal skin tissue and 43 cases of CSCC were measured using SP immunohistochemistry staining method. Results： A weak expression or no expression of E- cadherin was found in 30 CSCC cases （69.8 % ）, including 19 （61.3 % ） cases without lymphonode metastasis and 11 （91.7 % ） cases with lymphonode metastasis. Positive expression of MMP - 2 was found in 34 CSCC cases （79.1% ）, including 23 （74.2 % ） cases without lymphonode metastasis and 11 （91.7%） cases with lymphonode metastasis. Conclusion： The down- regulation of E- cadherin and up- regulation of MMP- 2 may closely be correlated to lymphonode metastasis of CSCC.
作者 魏志平 李艳 刘彦群
机构地区 徐州医学院附属医院皮肤科
出处 《中国麻风皮肤病杂志》 2007年第4期274-276,共3页 China Journal of Leprosy and Skin Diseases
关键词 E-钙黏蛋白 MMP-2 皮肤鳞状细胞癌 转移 E- cadherin MMP- 2 cutaneous squamous cell carcinoma metastasis
分类号 R739.5 [医药卫生—肿瘤]
  • 相关文献

参考文献7

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二级参考文献7

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同被引文献37

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中国麻风皮肤病杂志
2007年 第4期

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