呕吐动物模型的研究进展及评价

Review and evaluation of vomiting animal models

该文介绍了目前国外应用较多的几种呕吐模型动物:雪貂,目前最理想的呕吐模型动物。国内有人用水貂替代雪貂,证明切实可行;钱鼠(suncus murinus,house muskshrew),用于呕吐模型的最小的哺乳动物;大鼠没有呕吐反射,但是其异食痞行为可视为呕吐指标。不同种属动物对不同催吐剂的敏感性不同。

Only limited species of animals with vomiting reflex are available for the vomiting animal models. From 1980s some new vomiting models have been developed, such as in ferret, which is convinced its vomiting behavior is closest to human being; Suncus murinus（ house musk shrew）is the smallest mammal used in vomiting model and the most sensitive animal to motion sickness; rat, although without vomiting reflex, but consuming non-nutritive substance such as kaolin（pica） can be considered to be an index of nausea and vomiting; mink, from the same genus as ferret, can be a substitute of ferret in vomiting model. It should be noted that the sensitivity profile to different emetic stimuli is species-dependent.