维持性血液透析患者C反应蛋白水平与血清蛋白浓度的关系

Study on the relationship between C-reactive protein and serum protein in hemodialysis patients

目的:探讨维持性血液透析患者C反应蛋白(CRP)水平与血清白蛋白(ALB),前白蛋白(PA)及转铁蛋白(TF)之间的关系。方法:选择稳定透析半年以上血透患者56例,分为C反应蛋白正常组(CRP≤8mg/L)和升高组(CRP>8mg/L),比较两组间血红蛋白(HB)、白清白蛋白、前白蛋白、转铁蛋白的差别,并分析CRP与血红蛋白(HB)、白清白蛋白、前白蛋白、转铁蛋白之间的关系,透析前测定并计算尿素清除指数(Kt/v)。结果:血液透析患者CRP升高组的Hb、ALB、PA、TF均低于CRP正常组,两组有显著性差异(P<0.05)。且CRP水平与ALB、PA、TF成负相关,与Kt/v无关。结论:CRP可作为预测血清蛋白浓度的标准之一。

Objective：To study the correlation between C-reactive protein （CRP） level and serum albumin, prealbumin and transferrin in maintenance hemodialysis patients. Methods：This study enrolled in 56 maintenance hemodialysis patients who were followed up for more than 6 months in dialysis center of XuanWu hospital. The serum levels of CRP, hemoglobin, albumin, prealbumin, transferrin were measured. Blood urea nitrogen was measured in order to calculate urea clearance index before and after hemodialysis. The patients were divided into high CRP group and normal CRP group. Results： Alb, pre-Alb and TF were much more lower in high CRP group comparing with the normal CPRP group （ P 〈 0.05 ）. There was negative correlation between CRP and Alb, pre-Alb and TF. However, there was no correlation between CRP and Kt/v by statistics analysis. Conclusion：CRP may be a useful marker for prognoses the concentration of serum protein in hemodialysis patients.