摘要
目的建立一种中药生产过程中料液混合终点的在线判断方法。方法用透反射光纤探头在线采集混合过程中料液的近红外光谱,以光谱偏差作为混合均匀度指标,判断混合终点。结果应用本法对复方丹参滴丸料液的混合过程进行在线终点判断,随后制备成滴丸,结果表明,经本法终点判断后制备的滴丸丸重均匀,有效成分含量稳定,能有效保证产品质量。结论本法可快速准确地对复方丹参滴丸料液混合终点实现在线判断。
OBJECTIVE To develop a rapid method for on-line endpoint determination in blending process of dripping solution by near infrared spectroscopy. METHODS A fibre optic probe was utilized for on-line near infrared trans-flectance spectral data collection. The standard deviations between spectra were calculated as the index of mixture uniformity, and then the endpoint was determined. RESULTS This method was utilized to determine the endpoint in blending process, and samples of compound danshen dripping pills were produced according to this endpoint. The weight and the contents of danshensu were found uniform. CONCLUSION The method for on-line endpoint determination of dripping solution is rapid and accurate.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2007年第7期509-511,共3页
Chinese Pharmaceutical Journal
基金
国家"十五"重大科技攻关计划项目资助(2001BA701A45)
浙江省科技厅重大科技计划项目(021103549)
关键词
近红外
透反射光谱
复方丹参滴丸
混合过程
在线终点判断
NIR
near infrared trans-flectance spectroscopy
compound danshen dripping pills
blending process
on-line endpoint determination