一步合成3-酮-Δ^(4,6)甾体化合物

One-Step Synthesis of 3-oxo-Δ^(4,6) Steroids

目的研究用3-羟基-Δ5甾体化合物为原料合成3-酮-Δ4,6甾体化合物。方法利用溴、溴化锂和助催化剂吡啶方法同时进行氧化脱氢。结果得到目标化合物,精品收率达60%以上。结论用该法收率高,成本低且一步合成。

OBJECTIVE To study the synthetic process for 3-OxO-△^4＇6 steroids using 3-hydroxy-△^5 steroids as starting materials. METHODS Using the bromine, the lithium bromide and the promoter pyridine carried out the oxidized dehydrogenation. RESULTS The target compound was obtained and purified yield was over 60%. CONCLUSION The process provides high yields with inexpensive cost and has one-step synthesis.