中药配合双环醇治疗慢性乙型肝炎57例疗效观察

Clinical observation of traditional medicine combined with bicyclol on chronic hepatitis B

目的观察中西结合治疗慢性乙型肝炎患者的近、远期疗效。方法将100例慢性乙型肝炎患者随机分为治疗组57例、对照组43例，治疗组服用中药加双环醇片，对照组服用双环醇片，治疗12个月，于治疗前、中、后及停药6个月后检测肝功能及乙肝病毒标志物的变化。结果治疗结束后，两组均能明显改善患者血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、γ-谷氨酰氨基转肽酶（GGT）、白蛋白（A）、球蛋白（G）、总胆红素（TBiL），其中治疗组升高白蛋白、降低球蛋白的作用优于对照组（P〈0．05）。停药6个月后，治疗组在改善ALT、A、G、TBiL方面优于对照组（P〈0．05）；治疗结束后，治疗组HBV-DNA阴转率优于对照组（P〈0．05）。停药6个月后，治疗组（43．9％）与对照组（23．2％）的HBV-DNA阴转率差异有统计学意义，对照组的反跳率（3／43）明显高于治疗组（0）。结论中药加双环醇可降低慢性乙型肝炎患者HBV-DNA含量，改善肝功能，近、远期疗效优于单用双环醇片。

Objective To objective the short and long term effect of traditional medicine combined with bicyclol on chronic hepatitis B. Methods .100 patients with chronic hepatitis B were randomized into 2 groups： therapy group（57 cases） and control group（43 cases）. The patients in therapy group were given traditional medicine plus bicyclol for 12 months. The patients in control groups were given bicyclol for 12 months. Liver function and the markers of hepatitis B virus were tested at the times of before, middle, end and 6 months after the treatment. Results After 12 months therapy,the levels of ALT,AST,GGT,TBiL and GLB were lower than before,the level of ALB was increased. Compared to control group, the level of ALB was higher, and the level of GIb was lower in therapy group （P 〈 0.05）. Compared to control group, the levels of ALT, GIb, TBiL were lower, and ALB was higher in therapy group（ P 〈 0.05 ） at 6 months after therapy. The negative rate of HBV-DNA in patients of therapy group was higher than control at the rimes of the end of the therapy and 6 months follow up. The rate of relapse was higher for patients in control groups than therapy group（ P 〈 0.05 ）. Conclusion Chinese traditional medicine plus bicyclol can decrease the level of HBV-DNA and improve the liver function for patients with hepatitis B.