复发性难治性急性白血病21例临床分析

The therapeutic efects of FLAG regime for refractory and relapsing acute leukemia

目的观察氟达拉滨（Flu）、阿糖胞苷（Ara-C）及粒细胞集落刺激因子（G-CSF）（FLAG）方案对复发性难治性急性白血病的疗效与不良反应。方法Flu 30mg·m^-2·d^-1，1～5d；Ara-C1．5g·m^-2·d^-1，5d；在WBC〈1×10^9／L时用G-CSF5μg·kg^-1·d^-1直至WBC〉1．5×10^9／L。治疗21例复发难治急性白血病。结果总有效率81％（17／21），CR57％（12／21），PR24％（5／21），NR14％（3／21）。发生中性粒细胞缺乏16例，持续时间6～18d，血小板〈20×10^9／L 13例，持续时间7～20d。不良反应包括丙氨酸氨基转移酶（ALT）升高、发热、腹泻。结论FLAG方案治疗复发性难治性急性白血病疗效较好，不良反应较少。

Objective To investigate the therapeutic curative effect of FLAG regimen for refractory and relapsing acute leukemia. Methods Fludarabine 30mg·m^-2·d^-1,1-5 days,Ara-C 1.5g·m^-2·d^-1 ,5 d and G-CSF 5μg·kg^-1·d^-1 were used to treat 21 cases of refractory and relapsed leukemia. Results Total effective rate was 81 percent. 12 cases were complete remission, 5 cases were partial remission, 3 cases were non-remission. 16 cases occurred ncutropenia and last 5- 34 days, 13 cases occurred thrombocytopenia and last 5- 36 days. The adverse reaction included hyperamino transferase, pyrexia and diarrhea. Conclusion FLAG shows obvious curative effect for refractory and relapsing acute leukemia and has less adverse reaction.