脾动脉栓塞术在肝癌伴肝硬化脾功能亢进中的应用

Application of Partial Splenic Embolization in Treatment for Hepatocellular Carcinoma Complicated with Cirrhosis and Hypersplenism

目的探讨部分脾动脉栓塞术(PASE)对原发性肝癌伴肝硬化脾功能亢进综合治疗的应用价值。方法对20例在综合治疗过程中应用PASE的原发性肝癌伴肝硬化脾功能亢进患者的临床资料进行回顾性分析。结果PASE术后24h、48h、72h、1周的血白细胞和血小板均较栓塞前明显升高(P<0.05和P<0.01)。结论PASE能有效改善肝癌合并脾功能亢进患者的外周血象,控制脾功能亢进,减少术前及术中用血,提高患者手术耐受力,与肝动脉栓塞化疗联合应用,能延长生存期,提高生存质量。

Objective To evaluate the clinical effects of partial splenic embolization（PASE） in treatment for hepatocellular carcinoma with portal hypertension and hypersplenism. Methods A retropective research was done on the clinical data of 20 patients of hepatocellular carcinoma complicated with cirrhosis and hypersplenism,who were treated by PASE. Results Comparison with pre - embolization a significant increase in the peripheral leukocyte and platelet count was found 24h ,48h ,72h, 1 weeks after the embolization（ P 〈0. 05 and P 〈0. 01 ）. Conclusion Partial splenic embolization is an effective supporting therapy for hypersplenism in patients with hepatocellular carcinoma, which is helpful for hepatic arterial chemoembolization.