湖南省1996～2005年霍乱弧菌耐药性监测分析

Analysis on antibiotic resistance of Vibrio cholerae in Hunan Province from 1996 to 2005

目的：了解1996—2005年湖南省霍乱弧菌的耐药性和耐药性的变迁。方法：采用K—B法检测345株霍乱弧菌对8种抗菌药物的敏感性。结果：在测定的8种抗菌药物中，01群和0139群的霍乱弧菌对丁胺卡那、诺氟沙星、环丙沙星的敏感率最高，10年来未发现耐药菌株。两类菌在对四环素、强力霉素、红霉素和氨苄青霉素的耐药性上具有显著性差异。霍乱弧菌对复方新诺明、四环素、强力霉素、红霉素的耐药性从1996到2005年均有不同程度的上升。结论：长期对霍乱弧菌的耐药性进行监测和动态分析，可以为霍乱弧菌的流行病学研究以及对霍乱的监控和防治提供依据。

Objective： To understand the antibiotic resistance and it＇s variance in Hunan Province from 1996 to 2005. Methods： Susceptibility to 8 antimicrobial agents was tested by K - B method in 345 isolates. Results： Of the entire 8 antimicrobial agents, amikacin, norfloxacin and ciprofloxacin had the highest susceptibility rate for Vibrio cholerae O1 strains and O139 strains, and the resistance strains had not been found in ten years. The two kinds of Vibrio cholerae strains had the significant difference in the resistance of tetracycline, doxycycline, erythromycin and ampicillin. The drug resistance rate of trimethoprim and sulphame- thoxazole, tetracycline, doxycycline and erythromycin rose in different degrees from 1996 to 2005. Conclusion： The dynamic analysis of the antibiotic resistance surveillance for a long time can provide the basis for the epidemiologic studies on and the control of Vibrio cholerae.