糖尿病心肌病患者30例窦性心率震荡现象分析

The investigation of heart rate turbulence in 30 patients with diabetic cardiomyopathy

目的研究窦性心率震荡(HRT)在糖尿病心肌病(DC)患者中的变化,以及与心率变异性时阈指标(SDNN)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)的关系。方法选择DC患者30例,正常健康对照20名,根据24h动态心电图(Holter)记录资料,计算HRT的两个参数震荡初始(TO)和震荡斜率(TS),比较两组差别,并计算TO、TS与SDNN、LEVF、LEVDD之间的相关性。结果DC组TO值显著高于对照组[(3±5)%vs(-6±4)%,P<0.01];DC组TS值显著低于对照组[(6±6)/RR间期,P<0.01]。TO与SDNN、LVEF、LVEDD之间明显相关。结论DC患者室性早搏后的HRT现象变钝。

Objective To investigate the change of heart rate tubulence （HRT） in diabetic cardiomyopathy （DC） and its relationship with standard deviation of normal-to-normal RR interals （SDNN）, left ventricular ejection fraction （LVEF） and left ventricular end diastolic diameter （LVEDD）. Methods Thirty patients with DC and 20 control subjects were investigated. HRT on set and slope were measured by the original definitions using Holter records and its relevance with SDNN, LVEF and LVEDD was analysed. Results The value of the HRT on set was significantly higher in DC group than that in control group [ （3 ± 5） % vs （ - 6 ± 4） %, P 〈 0.01 ] ; the value of the HRT slope in 13（3 group was significantly lower than that in control group [（6 ± 6） ms/RR interval vs （13 ± 6） vs/RR interval, P〈 0.01 ]. There was a significant correlation between TO and SDNN, LVEF, LVEDD. Conclusion HRT is dramatically blunted in DC patients.