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VES诱导口腔鳞癌Tca8113细胞凋亡的实验研究

Bax Gene Expression in oral squamous cell carcinomas Tca8113
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摘要 目的明确VES对口腔鳞癌细胞Tca8113的作用,为临床应用VES防治口腔鳞癌提供科学的实验数据。方法RT-PCR法检测促凋亡基因bax在mRNA水平上的表达,Western blot检测促凋亡基因bax在蛋白水平上的表达。结果bax基因在mRNA水平上及蛋白水平上表达上调。结论VES诱导口腔鳞癌细胞Tca8113的凋亡作用,bax基因可能参与该过程。 Objective To probe into vitamin E succinate for selective antitumour activity in oral squamous cell carcinomas. Methods Using RT-PCR detected and quantified the expression of bax mRNA. Western blot measured relative amounts of the bax protein. Results Bax mRNA and protein levels upregulated. Conclusion The mechanism of apoptosis is possibly related to the expression of bax.
作者 宋晓冬 赵冬梅 杨军厚 杨玥 顾心彬
机构地区 滨州医学院基础学院 霍华德大学口腔学院肿瘤研究中心
出处 《滨州医学院学报》 2007年第2期85-86,共2页 Journal of Binzhou Medical University
基金 滨州医学院科技计划项目BY2005KJ02 美国NIH基金资助U54CA91409 P20CA118770-01
关键词 VES 口腔鳞癌 BAX基因 VES,oral squamous cell carcinomas,bax gene
分类号 R739.85 [医药卫生—肿瘤]
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滨州医学院学报
2007年 第2期

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