止消保肾汤对早期糖尿病肾病NO及SOD的影响

Influence of Zhixiaobaoshen Decoction on nitric oxide and superoxide dismutase in patients with early diabetic nephropathy

目的观察止消保肾汤对早期糖尿病肾病一氧化氮(NO)和超氧化物歧化酶(SOD)的影响。方法将入选的68例患者随机分为对照组和治疗组各34例,对照组使用洛汀新治疗,治疗组使用止消保肾汤治疗。观察治疗前后症状积分变化,测定空腹血糖(FPS)、尿微量白蛋白排泄率(UAER)、血清NO水平及SOD活性。结果治疗8周后,两组均能明显降低FPS、UAER及NO,升高SOD活性(P<0.01);对照组症状积分改善不明显(P>0.05),治疗组不仅能明显改善症状积分(P<0.01),而且在降低UAER及NO水平,升高SOD活性方面均明显优于对照组(P<0.05)。结论止消保肾汤能降低早期DN患者的症状积分及UAER,可能与降低NO水平、升高SOD活性有关。

Objective To observe the influence of Zhixiaobaoshen Decoction on nitric oxide （NO） and superoxide dismutase （SOD） in patients with early diabetic nephropathy（DN）. Methods Sixty-eight patients selected were randomly divided into the control group（n =34） and the treatment group（n =34）. The control group was treated with Lotensin and the treatment group was treated with Zhixiaobaoshen Decoction. Changes of symptoms, fasting plasma sugar （FPS）, urine albumin excretion ratio （UAER）, NO level and SOD activity in serum were observed. Results After 8 weeks treatsment, FPS, UAER and the NO level were obviously reduced and SOD activity was obviously elevated in both groups （P 〈 0. 01 ）, but the treatment group was better than the control group. The improvement of patients＇symptoms was obvious in the treatment group（P 〈 0. 05）, and was not obvious in the control group（P 〉0. 05）. Conclusion Zhixiaobaoshen DeCoction can improve the symptoms and reduce UAER of patients with early DN, which is possibly related to reducing the NO level and elevating the SOD activity.